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Contraindications Zofran pills is contraindicated in patients: known to pills have zofran hypersensitivity (e.g., anaphylaxis) to ondansetron zofran or any of the components of the formulation see Adverse Reactions (6.2). Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment of Fertility Carcinogenic effects were pills not seen in 2-year studies in rats and mice with oral ondansetron doses up to 10 mg/kg per day and 30 mg/kg per day, respectively (approximately 4 and. Last updated on pills Oct 1, 2018. Zofran orally disintegrating tablets may contain phenylalanine. Store liquid medicine in an upright position. Eye Disorders Cases of transient blindness, predominantly during intravenous administration, have been reported. Dispense in tight, light-resistant container as zofran defined in the USP. Additional information on the use of ondansetron in pediatric patients may be found in Zofran Injection prescribing information. The first 8-mg dose of Zofran was administered 30 minutes pills before the start of chemotherapy, with a online generic zofran subsequent dose 8 hours after the first dose, followed by 8 mg zofran sales in canada of Zofran twice a day for 2 days after the completion of chemotherapy. Store bottles upright in cartons. Drugs Affecting Cytochrome P-450 Enzymes Ondansetron does pills not itself appear to induce or inhibit the cytochrome P450 drugmetabolizing enzyme system of the liver see Clinical Pharmacology (12.3). The developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for Zofran and any potential adverse effects on the breast fed infant from Zofran or from the underlying maternal condition. Tell your doctor pills if you have phenylketonuria (PKU). Mean bioavailability in healthy subjects, following administration of a single 8mg tablet, is approximately. ZFT:9PI principal display panel NDC Zofran (ondansetron hydrochloride) Tablets 4 mg Each tablet contains 5 mg of ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron. This resulted in a significant increase in the clearance of ondansetron. Patient Counseling Information QT Prolongation Inform patients that Zofran may cause serious cardiac arrhythmias such as QT prolongation. Warnings and Precautions Hypersensitivity Reactions Hypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists. Avoid Zofran in patients with congenital long QT syndrome. In pills a doubleblind US trial in 336 patients receiving a cyclophosphamidebased chemotherapy regimen containing either methotrexate or doxorubicin, Zofran 8 mg administered twice a day was as effective as Zofran 8 mg administered 3 times a day in preventing nausea and vomiting. Zofran ODT orally disintegrating tablets are white, round, and plano-convex tablets available in the following strengths: 4 mg debossed with Z4 on one side. However, this association could be a chance finding, given the large number of drugs-birth defect comparisons in this study. Antacids: Concomitant administration of antacids does not alter the absorption of ondansetron. In a pre- and postnatal developmental toxicity study, pregnant rats received oral doses of ondansetron up to 15 mg/kg/day from Day 17 of pregnancy to litter Day. In addition to the adverse reactions listed above, the following adverse reactions have been described in the setting of ondansetron overdose: Sudden blindness (amaurosis) of 2 to 3 minutes duration plus severe zofran constipation occurred in one patient that was administered 72 mg. Before taking ondansetron, tell your doctor or pharmacist if you are allergic to it; or to other serotonin blockers (e.g., granisetron or if you have any other allergies. What Drugs Interact With Zofran? Chemotherapeutic Agents: Carmustine, etoposide, and cisplatin do not affect the pharmacokinetics of ondansetron see Drug Interactions (7.4). Before taking this medicine, you should not use Zofran if: you are also using apomorphine (Apokyn or you are allergic to ondansetron or similar pills medicines (dolasetron, granisetron, palonosetron). Do not push a tablet through the foil or you may damage the tablet. Specific Populations Age: Geriatric Population: A reduction in clearance and increase in elimination halflife are seen in patients older than 75 years compared to younger subjects see Use in Specific Populations (8.5). No overall differences in safety or effectiveness were observed between subjects 65 years of age and older and younger subjects. Patients received the first dose of Zofran (8 mg) or prochlorperazine (10 mg) 1 to 2 hours before the first daily radiotherapy fraction, pills with subsequent 8-mg doses approximately every 8 hours on each day of radiotherapy. Call your doctor for medical advice about side effects. Zofran can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or aids. With the exception of a slight decrease in maternal body weight gain in the rabbits, there were no significant effects of ondansetron on the maternal animals or the development of the offspring. Reported symptoms included somnolence, agitation, tachycardia, tachypnea, hypertension, flushing, mydriasis, diaphoresis, myoclonic movements, horizontal nystagmus, hyperreflexia, and seizure. In all instances, the adverse reactions resolved completely. Alfentanil and Atracurium Zofran does not alter the respiratory depressant effects produced by alfentanil or the degree of neuromuscular blockade produced by atracurium. Each 8-mg Zofran ODT orally disintegrating tablet for oral administration contains 8 mg ondansetron base. This may reflect some reduction of firstpass metabolism at higher oral doses. Each 5 mL of Zofran oral solution contains 5 mg of ondansetron hydrochloride dihydrate equivalent to 4 mg of ondansetron.
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